Wytheville, VirginiaFrom Wikipedia, the free encyclopedia Jump to: navigation, search Town of Wytheville, VirginiaTown Main Street in Wytheville Location in the Commonwealth of VirginiaCoordinates: 36°56′52″N 81°05′13″W / 36.94778°N 81.08694°W / 36.94778; -81.08694Coordinates: 36°56′52″N 81°05′13″W / 36.94778°N 81.08694°W / 36.94778; -81.08694Cou..